
10 Unexpected Physical Symptoms of Anxiety
Anxiety isn’t just mental—it can trigger 10 surprising physical symptoms and weaken your immune system. Learn what to watch for.
The friendships in your life do more than just bring joy or frustration—they have a profound impact on your brain, mental health, and even physical well-being. Research shows that strong female friendships at any age help reduce stress, boost oxytocin (the bonding hormone), and contribute to a longer, healthier life.
Yet, in today’s fast-paced digital world, face-to-face connections are often replaced by online interactions, increasing stress and feelings of isolation.
Understanding the science behind female friendships can help you cultivate meaningful connections that support your emotional resilience and overall well-being. But not all friendships are beneficial—some can become toxic, draining your energy and negatively affecting your brain health.
Learning how to build healthy, supportive friendships while recognizing when it’s time to step away is key to thriving mentally, emotionally, and physically.
Female friendships do more than just bring joy or frustration—they have a profound impact on your brain, mental health, and even physical well-being.
Unlike friendships among men who often need a shared activity to connect, women typically root their connection in deeper emotional support. Women’s friendships have a distinct depth, shaped by biology and psychology.
These sociological differences make it a powerful protective factor that can combat anxiety, depression, and even cognitive decline. It’s one of the reasons why women need strong friendships.The Role of Oxytocin in Female Bonding
Oxytocin, often called the “bonding hormone,” plays a key role in female friendships. When women engage in meaningful social interactions, their oxytocin levels rise and create feelings of trust, connection, and stress relief among each other.
A 2021 study published in The International Journal on the Biology of Stress found that oxytocin may have cardio-protective effects for women due to it reducing cortisol levels, calming the parasympathetic nervous system, and stabilizing the emotional regions of the brain.
Related: Oxytocin: 13 Natural Ways to Increase the Love Hormone
Women’s natural inclination to seek social bonds in times of stress is known as the “tend-and-befriend” response, a term coined by researchers at UCLA. Instead of withdrawing or reacting aggressively under stress, women instinctively nurture others and form alliances within their communities.
This behavior acts as a buffer against anxiety and depression while also finding solutions for certain circumstances. Both biological mechanisms show the benefits of female friendships for emotional well-being and mental stability.
If you want to know how friendships improve mental health, look at the brain. Beyond emotional support, friendship strengthens social connections and mental health in women by triggering the release of dopamine and serotonin—the neurotransmitters responsible for feelings of happiness and contentment. This explains why spending time with close friends has a mood-boosting effect comparable to physical exercise.
In addition to promoting happiness, having female friends also serves as a protective factor against cognitive decline. As women make up nearly two-thirds of Alzheimer’s cases in the U.S., it’s important to study what can mitigate and prevent the cause of this neurodegenerative disease. Women who maintain strong and intentional friendships are more likely to stay mentally sharp as they age.
Related: Alzheimer’s is a Lifestyle Disease
These friendships also provide an essential outlet to regulate emotions during times of stress. Consistently sharing deep thoughts, fears, and frustrations with a trusted friend allows women to process emotions more effectively, reducing the risk of developing stress-related disorders.
Research shows that social engagement in midlife significantly reduces the risk of dementia by 38% and mild cognitive impairments by 21% in later years. This aspect of any friendship is particularly important in modern society where chronic stress and mental health challenges are on the rise and not slowing down anytime soon.
One of the most compelling findings in social science is that women with close social connections tend to live longer than those who experience isolation. These friendships also contribute to stronger immune function and disease resistance.
Here are some of the ways strong female friendships can improve overall health:
Studies show that women with strong social support networks are less likely to experience or at least reduce the effects from depression, anxiety, and PTSD. This is important as loneliness can increase your risk of certain mental health disorders.
Loneliness and social isolation significantly increase health risks, according to research in the journal Heart. Having weak social connections increased the risk of coronary heart disease by 29% and stroke by 32%.
Women with strong friendships tend to have better cardiovascular health, as meaningful connections help reduce feelings of loneliness, lower blood pressure, and support better heart function.
It turns out that friendships can increase longevity due to the ability to reduce cortisol levels from chronic stress and promote emotional resilience through better communication. There’s also research behind having a strong emotional support system during difficult times that shows it provides improved stress resilience.
Something else to keep in mind with female friendships is that they evolve throughout different phases of life. The unique forms of support in each stage can determine everything from health outcomes to how well you handle unexpected life events.
There’s a reason why friendships are important for women’s health, but it’s important to be aware that not all social bonds are healthy. Toxic friendships can be emotionally draining and socially isolating in and of themselves.
Press Play for More on Toxic Relationships
Hosted by Dr. Daniel Amen and Tana Amen, this episode of the Change Your Brain Every Day podcast reveals what can turn a good friendship into a toxic relationship.
Click below to tune in.
10 Ways to Ruin Your Relationships.
Recognizing the warning signs of an unhealthy friendship to protect your mental health can be tough. Some red flags of a toxic friendship can include:
These kinds of negative social interactions can increase cortisol levels and prolong emotional distress. Setting healthy boundaries is essential when dealing with toxic friends. As women, that can be more difficult as that “tend-and-befriend” response kicks in.
Prioritizing mental health means recognizing when a relationship is doing more harm than good, so don’t be afraid to address the issue or step away from an unhealthy friendship altogether. Learning to avoid toxic friendships is critical to your mental health.
Maintaining healthy friendships should be one of your top priorities in life. Making an intentional effort to nurture your relationships benefits your mental and physical health.
One of the simplest yet most effective ways to strengthen friendships is through regular communication. Even small check-ins, such as a thoughtful text or a quick chat over the phone, can reinforce emotional bonds.
Consistency is key and fosters trust and connection over time. Another way is through small acts of kindness, such as sending a supportive message or planning a casual get-together to deepen your friendship.
Research shows that building new adult relationships can be challenging, but it is possible and wholly beneficial. If you’re looking to expand your social circle, think about joining community groups, book a class, or go to a club focused on a shared hobby. You can also participate in fun local events to create opportunities to form meaningful connections.
Bedrov A, Gable SL. Thriving together: the benefits of women’s social ties for physical, psychological and relationship health. Philos Trans R Soc Lond B Biol Sci. 2023 Jan 16;378(1868):20210441. doi: 10.1098/rstb.2021.0441. Epub 2022 Nov 28. PMID: 36440568; PMCID: PMC9703221.
Young Kuchenbecker, S., Pressman, S. D., Celniker, J., Grewen, K. M., Sumida, K. D., Jonathan, N., … Slavich, G. M. (2021). Oxytocin, cortisol, and cognitive control during acute and naturalistic stress. Stress, 24(4), 370–383. https://doi.org/10.1080/10253890.2021.1876658
Taylor, S. E. (2011). Tend and befriend theory. UCLA Psychology Department. Retrieved from https://taylorlab.psych.ucla.edu/wp-content/uploads/sites/5/2014/11/2011_Tend-and-Befriend-Theory.pdf
Martino J, Pegg J, Frates EP. The Connection Prescription: Using the Power of Social Interactions and the Deep Desire for Connectedness to Empower Health and Wellness. Am J Lifestyle Med. 2015 Oct 7;11(6):466-475. doi: 10.1177/1559827615608788. PMID: 30202372; PMCID: PMC6125010.
Beam CR, Kaneshiro C, Jang JY, Reynolds CA, Pedersen NL, Gatz M. Differences Between Women and Men in Incidence Rates of Dementia and Alzheimer’s Disease. J Alzheimers Dis. 2018;64(4):1077-1083. doi: 10.3233/JAD-180141. PMID: 30010124; PMCID: PMC6226313.
Chen, Y., Grodstein, F., Capuano, A. W., Wang, T., Bennett, D. A., & James, B. D. (2025). Late-life social activity and subsequent risk of dementia and mild cognitive impairment. Alzheimer’s & Dementia, 21(1), e14316. https://doi.org/10.1002/alz.14316
Claudia Trudel-Fitzgerald, Emily S Zevon, Ichiro Kawachi, Reginald D Tucker-Seeley, Francine Grodstein, Laura D Kubzansky, The Prospective Association of Social Integration With Life Span and Exceptional Longevity in Women, The Journals of Gerontology: Series B, Volume 75, Issue 10, December 2020, Pages 2132–2141, https://doi.org/10.1093/geronb/gbz116
University of Cambridge. (2025, January 3). Social connections may boost immunity and reduce disease risk. www.news-medical.net/news/20250103/Social-connections-may-boost-immunity-and-reduce-disease-risk.aspx
Li G, Li Y, Lam AIF, Tang W, Seedat S, Barbui C, Papola D, Panter-Brick C, Waerden JV, Bryant R, Mittendorfer-Rutz E, Gémes K, Purba FD, Setyowibowo H, Pinucci I, Palantza C, Acarturk C, Kurt G, Tarsitani L, Morina N, Burchert S, Patanè M, Quero S, Campos D, Huizink AC, Fuhr DC, Spiller T, Sijbrandij M, Hall BJ. Understanding the protective effect of social support on depression symptomatology from a longitudinal network perspective. BMJ Ment Health. 2023 Nov 29;26(1):e300802. doi: 10.1136/bmjment-2023-300802. PMID: 38030405; PMCID: PMC10689368.
Valtorta NK, Kanaan M, Gilbody S, et al. Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies. Heart 2016;102:1009-1016. https://heart.bmj.com/content/102/13/1009
Southwick SM, Sippel L, Krystal J, Charney D, Mayes L, Pietrzak R. Why are some individuals more resilient than others: the role of social support. World Psychiatry. 2016 Feb;15(1):77-9. doi: 10.1002/wps.20282. PMID: 26833614; PMCID: PMC4780285.
Davis, E. (2023, May 5). 5 signs that a friendship has turned toxic. Psychology Today.www.psychologytoday.com/us/blog/invisible-bruises/202305/5-signs-that-a-friendship-has-turned-toxic
Pay, C. (2024). Using communication to strengthen friendship. Utah State University Extension. https://extension.usu.edu/confidence-project/research/using-communication-to-strengthen-friendship
Litchford, A. (2025). The power of kindness. Utah State University Extension. https://extension.usu.edu/relationships/faq/the-power-of-kindness
Pezirkianidis, C., Galanaki, E., Raftopoulou, G., Moraitou, D., & Stalikas, A. (2023). Adult friendship and wellbeing: A systematic review with practical implications. Frontiers in Psychology, 14, Article 1059057. https://doi.org/10.3389/fpsyg.2023.1059057
Cronin, A. M. (2015). ‘Domestic friends’: Women’s friendships, motherhood and inclusive intimacy. Sociological Research Online, 20(1), 9. https://doi.org/10.5153/sro.3547
Rosemary Blieszner, Aaron M Ogletree, Rebecca G Adams, Friendship in Later Life: A Research Agenda, Innovation in Aging, Volume 3, Issue 1, January 2019, igz005. https://doi.org/10.1093/geroni/igz005
Anxiety isn’t just mental—it can trigger 10 surprising physical symptoms and weaken your immune system. Learn what to watch for.
Learn how to stop catastrophic thinking in three simple steps to reduce anxiety, reframe fear, and regain control of your mind.
Our podcast is back! Keep your brain healthy by listening to Change Your Brain Every Day, hosted by Daniel Amen, MD & Tana Amen! Tune In